BETA THALASSEMIA: In beta thalassemia, the heterozygous state (called thalassemia minor) is accompanied by no symptoms or at most by very mild anemia. Only one of the two β globin alleles contains a mutation, so β chain production is not terribly compromised and patients may be relatively asymptomatic. Folic … Learn about the signs, how it’s diagnosed & treated. If one parent has beta thalassemia trait and the other parent has normal hemoglobin A, there is a 50 percent (1 in 2) chance with each pregnancy of having a child with beta thalassemia trait . Beta thalassemia is a recessive genetic disorder of hemoglobin structure. This condition is called beta thalassemia trait (also called beta thalassemia minor) and can cause mild anemia. Beta thalassemia minor (beta thalassemia trait) is the mildest form. Many times people with thalassemia are prescribed a supplemental B vitamin, known as folic acid, to help treat anemia. If you have mild anemia, folic acid supplements can help. In people with beta thalassemia, low levels of hemoglobin lead to a lack of oxygen in many parts of the body. This rule will usually not apply in cases of beta thalassemia, particularly beta thalassemia minor where the RBCs are not normochromic and are microcytic, and where there is a disproportionate number of … Beta thalassemia most often occurs in people of Mediterranean origin. 1,5% global population are heterozygotes for this disease. The one gene defect, beta thalassemia trait (minor), is asymptomatic and results in microcytosis and mild anemia. Unlike Thalassemia Major, Thalassemia Minor has only one defective beta globin gene Thalassemia is a genetic blood disorder that impacts the ability of the blood to get oxygen to the body’s organs. Beta thalassemia is a blood disorder that reduces the production of hemoglobin. Beta-thalassemia results of a default in the hemoglobin beta-chain synthesis. The homozygous form of beta thalassemia (thalassemia major) is not immediately lethal because there is some production of Hb F, which does not contain beta chains. β thalassemia minor is caused by a β/β o or β/β + genotype. Beta thalassemia minor is usually without clinical significance. An inherited blood disorder (usually clinically asymptomatic) resulting from the heterozygous inheritance of beta-thalassemia mutation or deletion in the beta-globin (HBB) gene on chromosome 11. This is sometimes referred to as "the rule of threes." If the synthesis from both genes … People with thalassemia minor or trait usually do not need blood transfusions because they either do not have anemia or have only a mild anemia. 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