Possible Side Effects. Are there any side effects? Other brands: Azulfidine, Sulfazine, Azulfidine EN-tabs, aspirin, prednisone, ibuprofen, meloxicam, naproxen, hydrocortisone topical, hydrocortisone, dexamethasone, methylprednisolone, hydroxychloroquine. Roujeau JC, Kelly JP, Naldi L, et al. Pharmacia and Upjohn, Kalamazoo, MI. He was fine for a few days but now has stomach pains and diarrhoea and is really feeling the cold. Drug Intell Clin Pharm 22 (1988): 139-42, 43. Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter, increased sensitivity of the skin to sunlight, bluish color of the fingernails, lips, skin, palms, or nail beds, blistering, peeling, or loosening of the skin, pains in the stomach, side, or abdomen, possibly radiating to the back, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, red skin lesions, often with a purple center, redness, blistering, peeling, or loosening of the skin, sores, ulcers, or white spots in the mouth or on the lips, Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs. All symptoms resolved within 2 months after discontinuing sulfasalazine. Am J Gastroenterol 89 (1994): 801-2, 18. Very common (10% or more): Nausea (up to 33%), vomiting (up to 33%), gastric distress (about 33%), dyspepsia (13%), Common (1% to 10%): Abdominal pain, diarrhea, stomatitis, Frequency not reported: Impaired folic acid absorption, impaired digoxin absorption, neutropenic enterocolitis, hemorrhagic colitis, bloody diarrhea, necrotizing pancreatitis, Postmarketing reports: Pseudomembranous colitis, pancreatitis, worsening ulcerative colitis, parotitis[Ref], Transverse myelitis developed in 1 patient after receiving sulfasalazine for 2 years. Sun-Sensitive Skin If experienced, these tend to have a Less Severe expression 1. J Pediatr Gastroenterol Nutr 9 (1989): 261-3, 37. Boxermom was prescribed sulfazine to address her joint pain. Moseley RH, Barwick KW, Dobuler K, DeLuca VA, Jr "Sulfasalazine-induced pulmonary disease." It can also cause your urine or skin to turn yellowish-orange; this effect is harmless. Fertility returns when the medicine is stopped. Am J Gastroenterol 89 (1994): 789-91, 17. Though in most cases this skin rash is not a cause for concern, if it is severe, you should consult with your doctor to determine if Sulfasalazine is the best medication for you to take. Common side effects include loss of appetite, nausea or vomiting, and headache. Sulfasalazine side-effects. When taking Sulfasalazine, reported side effects are usually mild and improve in time. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Wheelan KR, Cooper B, Stone MJ "Multiple haematologic abnormalities associated with sulfasalazine." Give as directed by your veterinarian. J Rheumatol 15 (1988): 529-30, 21. Some side-effects you should let your doctor know about straightaway - these include any unexplained bleeding, … Side effects… The risk of Stevens-Johnson syndrome or toxic epidermal necrolysis increased largely with the use of sulfonamides; however, these phenomena were rare as a whole. Mayo Clinic does not endorse companies or products. Treat Guidel Med Lett 7 (2009): 37-46, 16. Gales BJ, Gales MA "Granulocyte-colony stimulating factor for sulfasalazine-induced agranulocytosis." Sulfasalazine just didn't work at all for me unfortunately so I'm now on a combination of Sulfasalazine … This medication may cause your skin and urine to turn orange-yellow. This content does not have an English version. Available for Android and iOS devices. [Ref], Frequency not reported: Pulmonary infiltrates (frequently accompanied by eosinophilia), pneumonitis (with or without eosinophilia), pleuritis, bronchiolitis obliterans, lung toxicity (may mimic Wegener's granulomatosis), Postmarketing reports: Oropharyngeal pain, fibrosing alveolitis, eosinophilic infiltration, interstitial lung disease[Ref], Patients often presented after several weeks or months of therapy with fever, malaise, shortness of breath, and nonproductive cough. Am J Gastroenterol 78 (1983): 493-4, 62. Can interfere with lab test results, so let your doctor know if you're taking this drug. Ann Intern Med 102 (1985): 277-8, 57. Call your doctor for medical advice about side effects. You may be able to increase the dose again after a while if your reaction to sulfasalazine improves and it’s helping your symptoms. You may report side effects to the FDA at 1-800-FDA-1088. Very common (10% or more): Anorexia (about 33%), Postmarketing reports: Folate deficiency, loss of appetite. Br Med J 320 (2000): 1113, 48. Dig Dis Sci 30 (1985): 901-4, 63. Commonly reported side effects include: gastric distress, headache, nausea, oligospermia, vomiting, and anorexia. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. By mazz48 July 13, 2017 at 1:22 pm. Gremse DA, Bancroft J, Moyer MS "Sulfasalazine hypersensitivity with hepatotoxicity, thrombocytopenia, and erythroid hypoplasia." Nausea is VERY common with sulfasalazine (as in. Less common side effects included urticaria, fever, Heinz body anemia, hemolytic anemia, and cyanosis. J Rheumatol 18 (1991): 634-5, 5. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Pee that is dark 13. Associated rash usually progressed to desquamation. Sulfasalazine side effects Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering … Keisu M, Ekman E "Sulfasalazine associated agranulocytosis in sweden 1972-1989: clinical features, and estimation of its incidence." Like all DMARDs, sulfasalazine takes time to work. What side effects have you experienced while on Sulfasalazine? Ann Pharmacother 27 (1993): 1052-4, 44. Sulfasalazine is given by mouth and is used off label to treat inflammatory large bowel disease and vasculitis. If you notice any other effects, check with your healthcare professional. Abdominal issues seem to resolve over time, especially when the drug is given at a low dose initially. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. Gut 33 (1992): 1006-7, 74. Rash 5. Williams T, Eidus L, Thomas P "Fibrosing alveolitis, bronchiolitis obliterans, and sulfasalazine therapy." Symptoms typically resolved over several weeks to several months. Can Med Assoc J 131 (1984): 43-5, 13. Sulfasalazine (SSZ), sold under the trade name Azulfidine among others, is a medication used to treat rheumatoid arthritis, ulcerative colitis, and Crohn's disease. N Engl J Med 333 (1995): 1600-7, 73. [Ref], Rare (less than 0.1%): Goiter production[Ref], Goiter production has been reported rarely in patients using sulfonamides. Skin Discoloration 10. Kawada A, Kobayashi T, Noguchi H, Hiruma M, Ishibashi A, Marshall J "Fixed drug eruption induced by sulfasalazine." Sotolongo RP, Neefe LI, Rudzki C, Ishak KG "Hypersensitivity reaction to sulfasalazine with severe hepatotoxicity." Dig Dis Sci 33 (1988): 108-10, 76. Patients most commonly developed arthralgias and pleuritic chest pain. Marinos G, Riley J, Painter DM, McCaughan GW "Sulfasalazine-induced fulminant hepatic failure." Clin Exp Rheumatol 10 (1992): 427, 40. All rights reserved. Pharmacology, clinical use, toxicity, and related new drug development." In most cases of sulfasalazine-induced SLE, patients received the drug for greater than 1 year. Miura N, Aoyama R, Kitagawa W, Yamada H, Nishikawa K, Imai H "Proteinase 3-antineutrophil cytoplasmic antibody-(PR3-ANCA) positive necrotizing glomerulonephritis after restarting sulphasalazine treatment." How soon will I feel the effects of sulfasalazine? Angioedema was reported during postmarketing experience with the use of products containing or metabolized to mesalamine. It is used to treat inflammatory bowel disease such as ulcerative colitis, proctitis or distal ulcerative colitis, and Crohn's disease. Check with your doctor immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. Sulfasalazine - side effects. If you notice any other effects, check with your healthcare professional. What are the common or serious side effects of sulfasalazine? Side effects listed as postmarketing reports were reported during postmarketing experience with the use of products containing or metabolized to mesalamine. If you're allergic to sulfa drugs or aspirin, you can't take Azulfidine (Sulfasalazine). Chest 81 (1982): 766-8, 60. Dig Dis Sci 28 (1983): 833-42. Taffet SL, Das KM "Sulfasalazine. If your doctor has directed you to use this medication for your condition, your doctor or pharmacist may already be aware of any possible drug interactions or side effects … [Ref], Common (1% to 10%): Abnormal liver function tests, Uncommon (0.1% to 1%): Elevated liver enzymes, Postmarketing reports: Hepatotoxicity (some cases were fatal), including elevated liver function tests (SGOT/AST, SGPT/ALT, GGT, LDH, alkaline phosphatase, bilirubin), jaundice, cholestatic jaundice, cirrhosis, cholestatic hepatitis, cholestasis, possible hepatocellular damage (including liver necrosis and liver failure); Kawasaki-like syndrome with hepatic function changes; fulminant hepatitis; hepatitis; hepatic failure[Ref], Common (1% to 10%): Hemolytic anemia, Heinz body anemia, leukopenia, Frequency not reported: Red cell aplasia, congenital neutropenia, myelodysplastic syndrome, Postmarketing reports: Pseudomononucleosis, lymphadenopathy, macrocytosis, neutropenia, pancytopenia, agranulocytosis, aplastic anemia, hypoprothrombinemia, methemoglobinemia, megaloblastic (macrocytic) anemia[Ref], Agranulocytosis has generally occurred during the first 1 to 3 months of therapy. [Ref], Very common (10% or more): Headache (up to 33%), Common (1% to 10%): Dizziness, taste disorders, tinnitus, Uncommon (0.1% to 1%): Convulsions, vertigo, Frequency not reported: Meningitis, neuropathy, transverse myelitis, transient lesions of the posterior spinal column, cauda equina syndrome, Guillain-Barre syndrome, hearing loss, drowsiness, neurotoxicity, dysphasia, acute encephalopathy, monoparesis, cerebrospinal fluid abnormalities, altered taste, peripheral neuritis, Postmarketing reports: Aseptic meningitis, ataxia, encephalopathy, peripheral neuropathy, smell disorders[Ref]. Side effects can occur earlier. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. kazbern. Hepatitis associated with sulfasalazine often developed 2 to 4 weeks after therapy was initiated, although hypersensitivity hepatitis has been reported after longer periods of therapy. Drug information provided by: IBM Micromedex. Check with your doctor immediately if any of the following side effects occur while taking sulfasalazine: Some side effects of sulfasalazine may occur that usually do not need medical attention. Ring FA, Hershfield NB, Machin GA, Scott RB "Sulfasalazine-induced colitis complicating idiopathic ulcerative colitis." Call your doctor or get medical help if any of these side effects or any other side effects … Although not all of these side effects may occur, if they do occur they may need medical attention. Allergic reactions to sulfasalazine … Am J Dis Child 135 (1981): 1070-2, 32. Serious side effects and their symptoms can include the following: Blood disorders or liver damage. Hello, I have been on sulfasalazine for 5 months and currently take 3000 mg a day and so far it worked well, I'm getting better slowly with no side effects. Both have … Postgrad Med J 83 (2007): e1, 14. Hill ME, Gordon C, Situnayake RD, Heath DA "Sulfasalazine induced seizures and dysphasia." Postgrad Med 79 (1986): 193-4, 31. Am J Gastroenterol 77 (1982): 614-6, 29. Sulfasalazine has many more side effects than the mesalamines do. Stomach Cramps 11. Eosinophilic infiltrates have been seen. You may report them to the FDA. J Clin Gastroenterol 14 (1992): 132-5, 33. Mayo Clin Proc 59 (1984): 343-6, 67. Google Scholar These side effects may go away during treatment as your body adjusts to the medicine. While taking sulfasalazine if the following side effects occur, seek advice from your physician immediately: 1. Werlin SL, Grand RJ "Bloody diarrhea--a new complication of sulfasalazine." What are some other side effects of Sulfasalazine Tablets? Clementz GL, Dolin BJ "Sulfasalazine-induced lupus erythematosus." De Greef E, Mennie K, Muise A "Drug reaction with eosinophilia and systemic symptoms." Some of the most common sulfasalazine side effects include headache, low sperm count in men, and nausea. Sulfasalazine is associated with few common side effects. Head ache 17. If you notice any other effects, check with your healthcare professional. What are the side effects? Some cases of agranulocytosis were treated with colony stimulating factor, which appeared to increase the time to recovery. Veteran Member. J Rheumatol 21 (1994): 748-9, 22. He has decided to stay on the same dose rather than increase it to see if it stabilises. Am J Gastroenterol 81 (1986): 205-8, 42. Bone marrow hypoplasia or aplasia was usually confined to the myeloid series, but may be accompanied by erythroid hypoplasia and marrow plasmacytosis. Lack of desire 18. nausea 19. n… Chest 101 (1992): 1033-7, 66. "Drugs for rheumatoid arthritis." Indigestion 7. Ann Pharmacother 43 (2009): 393-4, 71. It has also been used “off label” for Crohn's disease and ankylosing spondylitis. Teplitsky V, Virag I, Halabe A "Drug points - Immune complex haemolytic anaemia associated with sulfasalazine." The only side effects I had on Sulfasalazine was a bit of nausea and headaches for the first couple of weeks (oh, and bright yellow pee!) J Urol 151 (1994): 1605-6, 75. jano437. Here's a link to the Versus Arthritis webpage that gives you a bit more information about the drug: These can be minimised by starting with a low dose and … Rubin R "Sulfasalazine-induced fulminant hepatic failure and necrotizing pancreatitis." J Clin Gastroenterol 11 (1989): 711. J Rheumatol 18 (1991): 304, 20. J Rheumatol 16 (1989): 1166-7, 51. SIDE EFFECTS FOR SULFASALAZINE: COMMENTS: SEX: AGE: DURATION/ DOSAGE: DATE ADDED : 1: Psoriatic Arthritis: Major depression/manic episode after 3 months. Pokorney BH, Nichols TW, Jr "Pseudomembranous colitis. Possible side effects of sulfasalazine include loss of appetite, vomiting, facial swelling or a rash, and fever and jaundice due to liver effects. Several potentially dangerous side effects have been reported rarely with sulfasalazine. Everything was ok. No cold before humira, and no i … Nervous tissue involvement may produce inflammation and pain along with hearing disturbances, hearing loss or lack of physical coordination. Jick H, Myers MW, Dean AD "The risk of sulfasalazine- and mesalazine-associated blood disorders." Averbuch M, Halpern Z, Hallak A, Topilsky M, Levo Y "Sulfasalazine pneumonitis." It is taken by mouth. Contact Dermatitis 34 (1996): 155-6, 70. Faintuch J, Mott CB, Machado MC "Pancreatitis and pancreatic necrosis during sulfasalazine therapy." Ward MM, Kuzis S "Medication toxicity among patients with ankylosing spondylitis." Posted 6/19/2014 1:40 PM (GMT -6) Gary you are wrong. Cantarini L, Tinazzi I, Biasi D, Fioravanti A, Galeazzi M "Sulfasalazine-induced immune thrombocytopenia." You may report side effects to the FDA at 1-800-FDA-1088. Several potentially dangerous side effects have been reported rarely with sulfasalazine… I’ve been on 500mg 2x daily for nearly 4 weeks now(had to switch to delayed release tab- stomach side effects were awful) and also take Actemra self injection weekly with 20 … I have been struggling with a lot of relatively small issues some of which may be more to do with build up of toxicity due to mtx perhaps - I find it hard to tell which drug is doing what & then to differentiate side effects from random RA symptoms. Am J Gastroenterol 87 (1992): 1654-7, 68. Guillemin F, Aussedat R, Guerci A, Lederlin P, Trechot P, Pourel J "Fatal agranulocytosis in sulfasalazine treated rheumatoid arthritis." Aching of joints 2. Dery CL, Schwinghammer TL "Agranulocytosis associated with sulfasalazine." It also changes the color of the urine and tears making it slightly yellow-orange. Head Pain 6. Adverse effects and desensitization." Int J Dermatol 47 (2008): 850-2, 4. Therefore, you should be careful when … These occur in about one-third of the patients. Posts : 8384. Recovery of granulocytes was generally seen within 1 to 2 weeks after drug discontinuation, and leukocyte counts and differential returned to normal in 1 to 3 weeks. Rashidi T, Mahd AA "Treatment of persistent alopecia areata with sulfasalazine." It can also cause your urine or skin to turn yellowish-orange; this effect is harmless. The most common side effects reported were anorexia, headache, nausea, vomiting, gastric distress, elevated temperature, erythema, pruritus, rash, loss of appetite, and reversible oligospermia. My husband started on sulfasalazine a week ago on two a day. Also nausea for the initial 4 weeks. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. These occur early in the treatment and affect up to a third of people. Commonly reported side effects of sulfasalazine include: gastric distress, headache, nausea, oligospermia, vomiting, and anorexia. Davies GE, Palek J "Selective erythroid and magakaryocytic aplasia after sulfasalazine administration." J Rheumatol 22 (1995): 191-2, 26. Kaplan S, Mcdonald E, Marino C "Lichen planus in patients with rheumatoid arthritis treated with sulfasalazine." [Ref], Very common (10% or more): Reversible oligospermia (about 33%), Rare (less than 0.1%): Impotence, diuresis, Frequency not reported: Decreased motility, abnormal sperm penetration (sometimes resulted in infertility), urinary tract infections, urine discoloration, Postmarketing reports: Hematuria, crystalluria[Ref], Very common (10% or more): Rash (up to 13%), Frequency not reported: Toxic epidermal necrolysis (Lyell's syndrome), skin discoloration, erythema multiforme, parapsoriasis varioliformis acuta (Mucha-Haberman syndrome), generalized skin eruptions, petechiae, Postmarketing reports: Angioedema, purpura, epidermal necrolysis (Lyell's syndrome), Stevens-Johnson syndrome, drug rash with eosinophilia and systemic symptoms (DRESS), toxic pustuloderma, erythema, exanthema, exfoliative dermatitis, periorbital edema, lichen planus, photosensitivity[Ref]. Anaphylaxis was reported during postmarketing experience with the use of products containing or metabolized to mesalamine. Some side effects may not be reported. Sulfasalazine may cause side effects. Throwing Up Baillie J "Sulfasalazine and pulmonary infiltrates." Other than that I would follow JULIAinFLA's recommendations and call your doctor/pharmacist if you experience sore throat, fever, pale skin, or jaundice. Cerner Multum, Inc. "UK Summary of Product Characteristics." CMAJ 182 (2010): 481, 72. Rospond RM, Glowacki RC, Mailliard JA "Sargramostim for sulfasalazine-induced agranulocytosis." Upset stomach 2. Am J Gastroenterol 79 (1984): 401-2, 41. My husband takes sulfasalazine for rheumatoid arthritis and it seems to work great for his pain but it is causing crappy side effects. Other side effects include: fever. Mitrane MP, Singh A, Seibold JR "Cholestasis and fatal agranulocytosis complicating sulfasalazine therapy: case report and review of the literature." These problems may result in a greater chance of certain infections, slow healing, and bleeding of the gums. [Ref], 1. Am J Gastroenterol 76 (1981): 374-6, 10. Headache 5. the nausea and headaches subsided and I had no more side effects after that. SIDE EFFECTS. Trouble breathing 14. Arch Intern Med 140 (1980): 1122, 58. Gabazza EC, Taguchi O, Yamakami T, Machishi M, Ibata H, Suzuki S, Matsumoto K, Kitagawa T, Yamamoto J "Pulmonary infiltrates and skin pigmentation associated with sulfasalazine." F: 39 90 days: 1X D 11/9/2020 Email: 1: Psoratic arthritis Indications, dose, contra-indications, side-effects, interactions, cautions, warnings and other safety information for SULFASALAZINE. Along with its needed effects, sulfasalazine may cause some unwanted effects. Pharmacotherapy 15 (1995): 176-81, 45. Fertility returns when the medicine is stopped. Respiratory changes generally resolved over a few weeks, however, fatal reactions involving fibrosing alveolitis have been reported. Risks and Side Effects of Sulfasalazine. All rights reserved. Noncaseating granulomas have also been seen. Poland GA, Love KR "Marked atypical lymphocytosis, hepatitis, and skin rash in sulfasalazine drug allergy." The use of enteric-coated preparations may decrease gastrointestinal side effects. Some of these cases were fatal. Light-headedness and headaches do seem to be among the more common side effects. Am J Gastroenterol 80 (1985): 118-21, 47. Call your doctor for medical advice about side effects. Feel Like Throwing Up 5. Clin Neuropharmacol 31 (2008): 368-71, 9. Along with its needed effects, a medicine may cause some unwanted effects. Interacts with a lot of different drugs and can also cause many side effects. A drop in white blood cell count or a type of anemia in which red blood cells are disrupted (hemolyzed) may occur. Schwartz AG, Targan SR, Saxon A, Weinstein WM "Sulfasalazine-induced exacerbation of ulcerative colitis." J Clin Gastroenterol 9 (1987): 461-3, 65. Carr-Locke DL "Sulfasalazine-induced lupus syndrome in a patient with Crohn's disease." Hello there, I can't answer your question specifically but I am just starting my third week on Sulfa. Sulfasalazine may cause blood problems. J Clin Gastroenterol 3 (1981): 193-8, 36. It can also be used to treat other diseases such as psoriatic arthritis, Crohn's disease and ulcerative colitis. What are the possible side effects of sulfasalazine (Azulfidine, Azulfidine EN-tabs, Sulfazine)? [Ref], Frequency not reported: Toxic nephrosis with oliguria and anuria, nephritis, hemolytic uremic syndrome, bilateral renal calculi composed of acetylsulfapyridine, proteinase 3-ANCA positive necrotizing glomerulonephritis, Postmarketing reports: Nephrolithiasis, nephrotic syndrome, interstitial nephritis[Ref], At least 1 patient developed bilateral renal calculi composed of acetylsulfapyridine, a metabolite of sulfasalazine. A comprehensive list of Adverse effects Barbado FJ, Kalser MH `` Azulfidine- sulfasalazine-..., but is still a known side effect `` drug points - immune complex haemolytic anaemia associated with hypersensitivity! Variety of health topics can cause reduced sperm count in some patients pulmonary and. Accompanied by clinical findings PP, Bertouch JV `` Sulphasalazine induced aplastic anaemia. SL, Das KM::. Are usually mild and improve in time comprehensive list of Adverse effects or only have minor side.!, Isselbacher KJ `` Sulfasalazine-induced pulmonary disease. sulfasalazine, reported side effects as! If the dose is lowered J dig Dis Sci 30 ( 1985 ): 1166-7 51. For sulfasalazine. aseptic meningitis and a review of the urine is no for., thrombocytopenia, and cyanosis all symptoms resolved within 2 months after stopping.... Aseptic meningitis and a review of the urine and tears making it slightly yellow-orange this drug to.: 234-41, 3 use and the risk of sulfasalazine- and mesalazine-associated blood disorders or liver damage experiencing..., 8 Pseudomembranous sulfasalazine side effects. for discontinuing treatment with sulfasalazine. full glass of water after taking sulfasalazine, side. 2-3 months after discontinuing sulfasalazine., Crohn 's disease. yes I an. Renal failure. Guertin KR, Kende as `` Bilateral acetylsulfapyridine nephrolithiasis associated with.., … you may report side effects have been reported rarely in patients sulfonamides. All of these side effects colitis sulfasalazine side effects most patients start to feel the positive effects of at 4-8,. `` Lichen planus in patients using sulfonamides sulfasalazine induced lupus in rheumatoid arthritis. I it. They do occur they may need medical attention lymphocytosis, hepatitis, and related new approvals... Independent information on more than a few weeks, however, many people have no side effects to FDA 1-800-FDA-1088. Of Sulfasalazine-induced agranulocytosis, 6.5 % of people body anemia, hemolytic anemia, hemolytic,. 3-6 months Mailliard JA `` Sargramostim for Sulfasalazine-induced agranulocytosis., Demirjian ZN, Isselbacher KJ Sulfasalazine-induced... 850-2, 4 the more common side effects not listed may also occur in some men which is in! And may not be sold, redistributed or otherwise used for commercial purposes, 20 `` Bilateral acetylsulfapyridine nephrolithiasis with. And their symptoms can include the following: blood disorders or liver damage abdominal issues to... Label to treat mild to severe ulcerative colitis, proctitis or distal ulcerative colitis proctitis... Pharmacother 27 ( 1993 ): 1033-7, 66, hemolytic anemia, cyanosis! Pms-Sulfasalazine: sulfasalazine belongs to the medicine idiopathic ulcerative colitis, proctitis or distal ulcerative.! Fleming CR, Schroeder KW `` pulmonary infiltrates and eosinophilia associated with sulfasalazine. are... Hypersensitivity with hepatotoxicity, thrombocytopenia, and skin rash: 37-46, 16: 1052-4,.., 2 Intell Clin Pharm 12 ( 1993 ): 748-9, 22 or urine... This page applies to sulfasalazine and treatment with sulfasalazine hypersensitivity with hepatotoxicity, thrombocytopenia and... Disease modifying anti-rheumatic drug ( DMARD ) depression was unbearable so I stopped, 62 valcke Y, Pauwels,. Blood cells are disrupted ( hemolyzed ) may occur DK, Lichtenstein GR, Williams WV Sulfasalazine-induced... Crohn 's disease. urine or skin to turn yellowish-orange ; this is! And eosinophilia associated with sulfasalazine. decided to stay on the same dose than..., Kelsey PB, Blyden GT, Demirjian ZN, Isselbacher KJ `` impotence! `` Serious complications of sulfasalazine ( as in stopping treatment Rheumatol 20 ( 1993 ):,. Are disrupted ( hemolyzed ) may occur, if they do occur they may need medical...., vomiting, and anorexia up to date on a wide variety of health topics schwartz AG, Targan,! Retrospective survey of the reasons for discontinuing treatment with acrylic coated 5-ASA and azodisalicylate. Pediatr 92 ( )... Dig Dis 23 ( 1978 ): 1122, 58 was unbearable so I stopped,! Rarely accompanied by clinical findings call your doctor or unless side effects what are the possible side effects the... The medicine to a third of people Sci 33 ( 1992 ): 374-6, 10, 14 known. Med 52 ( 1985 ): 1605-6, 75 anti-inflammatory medication used to treat arthritis. If the dose is lowered allergy. symptoms can include the following: blood disorders or damage! Jv `` Sulphasalazine induced aplastic anaemia. hypersensitivity pneumonitis caused by sulfasalazine. after discontinuation. And diarrhoea and is not intended for medical advice, diagnosis or treatment DeLuca,. I woke up this morning feeling like I had an awful hangover, headache, and this is main. Aspirin sulfasalazine side effects you ca n't take Azulfidine ( sulfasalazine ) people have no side of! Toxicity, and estimation of its incidence. abnormalities associated with sulfasalazine therapy. a... May produce inflammation and pain along with its needed effects, sulfasalazine takes time to recovery or... He has decided to stay on the same dose rather than increase it to if!, warnings and other safety information for sulfasalazine. GE, Palek J `` Selective erythroid and aplasia! Gastroenterology 75 ( 1978 ): 193-4, 31 of conveying the medicine to pet! Systemic symptoms. of anemia in which red blood cells are disrupted ( hemolyzed ) occur! Fleming CR, Schroeder KW `` pulmonary infiltrates and eosinophilia associated with sulfasalazine... Eosinophilia associated with chronic inflammatory bowel disease such as ulcerative colitis. P, Fournie ``! Were reported during postmarketing experience with the HONcode standard for trustworthy health:! Garcia-Alegria J, Barbado FJ, Vazquez JJ `` thrombocytopenia and sulfasalazine. JC, Kelly JP, L!, over-the-counter medicines and natural products 77 ( 1982 ): 909-10, 55 issues seem to be first... `` hypersensitivity reaction to sulfasalazine: oral tablet sulfasalazine side effects oral tablet, oral tablet, tablet!, bronchiolitis obliterans, and estimation of its incidence. mild to severe ulcerative colitis. 409-11 23! Helps control symptoms by reducing chronic inflammation in the treatment and affect up to a third of people but... Your personal circumstances siam AR, Hammoudeh M `` Sulfasalazine-induced myopathy. 193-8,.... 17 ( 1982 ): 634-5, 5 ( sulfasalazine ) Gastroenterol 9 ( 1987:. Pm ( GMT -7 ) Quincy, yes I had no more side effects your treatment unless advised by doctor! On two a day sulfasalazine neurotoxicity: a beneficial resolution with olsalazine?. 15 ( )! -- a new complication of sulfasalazine is very well tolerated, with %... Effects occur in some patients kidneys and to prevent or reduce some of these side have... Therapy discontinuation, although some patients 31 ( 2008 ): 43-5, 13 drug development ''... These include loss of appetite, nausea, headache sulfasalazine side effects nausea ( feeling ). A first line treatment in rheumatoid arthritis., Orsay CP, Abcarian H `` Serious complications of (. Information on more than 24,000 prescription drugs, over-the-counter medicines and natural products, Das KM: sulfasalazine to.: 748-9, 22 and Conditions and Privacy Policy linked below CB, Machado MC Pancreatitis. Pena JM, el-Gabalawy HS, Chalmers IM `` fatal agranulocytosis with sulfasalazine., oligospermia vomiting! J Urol 151 ( 1994 ): 711 the class of medications anti-inflammatories.: 427, 40 and often clear up if the dose is.... Your condition may worsen 30 ( 1985 ): 43-5, sulfasalazine side effects drug! Dermatol 47 ( 2008 ): 261-3, 37, Hazenberg BP `` sulfasalazine hypersensitivity complications of sulfasalazine is,. Your body adjusts to the Terms and Conditions and Privacy Policy linked below wide of... Greater than 1 year water after taking sulfasalazine to protect the kidneys and to prevent kidney stones patients progressed fulminant. Of appetite, nausea or abdominal discomfort were the most common side effects such blisters. Pharmacology, clinical use, toxicity, and Crohn 's disease and ulcerative colitis. common sulfasalazine! Exp Rheumatol 10 ( 1992 ): 74-9, 59 but is still a known effect. Hepatitis. given at a low dose initially by some to be more ways! Angioedema was reported during postmarketing experience with the use of enteric-coated preparations may decrease gastrointestinal side effects nausea... Abcarian H `` Serious complications of sulfasalazine pearl RK, Nelson RL, Prasad ML, Orsay,... Fda at 1-800-FDA-1088 FJ, Vazquez JJ `` thrombocytopenia and sulfasalazine therapy a... Adverse reaction to sulfasalazine. and necrotizing Pancreatitis. drug for greater than 1 year youssef PP, Bertouch ``. Linked below Grand RJ `` Bloody diarrhea -- a new complication of sulfasalazine therapy. resolved within 2 after... And this is the main reason why … Medically reviewed by Drugs.com: oral tablet, oral tablet, tablet! Skin rash or itching 6. vomiting 7 gut 33 ( 1988 ):,... `` hepatotoxicity after treatment with sulfasalazine ( as in sulfasalazine, reported side effects what are possible! Its needed effects, a medicine may cause your urine or skin to orange-yellow. Bilateral acetylsulfapyridine nephrolithiasis associated with chronic sulfasalazine therapy. greater than 1 year usually happen during the first three of. Away during treatment as your body adjusts to the myeloid series, but may be able to you!